From his initial recognition as a young jazz lion, he has expanded his vision as an instrumentalist, composer, bandleader and educator, crossing stylistic boundaries while maintaining an unwavering creative integrity. In the process, he has become an avatar of contemporary artistic excellence winning three Grammy Awards, a Tony nomination for his work as a composer on Broadway, a citation by the National Endowment for the Arts as Jazz Master, and a 2021 Primetime EMMY nomination for the score he composed for the Tulsa Burning documentary.   

His first instrument, the clarinet, gave way to the alto and then the tenor and soprano saxophones when the teenage Branford began working in local bands.  A growing fascination with jazz as he entered college gave him the basic tools to obtain his first major jobs, with trumpet legend Clark Terry and alongside Wynton in Art Blakey’s legendary Jazz Messengers.  When the brothers left to form the Wynton Marsalis Quintet, the world of uncompromising acoustic jazz was invigorated.  Branford formed his own quartet in 1986 and it remains his primary performance vehicle. The Quartet has established a rare breadth of stylistic range, as demonstrated on the band’s last release:  The Secret Between the Shadow and the Soul. Known for the telepathic communication among its uncommonly consistent personnel, its deep book of original music replete with expressive melodies and provocative forms, and an unrivaled spirit in both live and recorded performances, the Branford Marsalis Quartet has long been recognized as the standard to which other ensembles of its kind must be measured. 

Branford formed the Marsalis Music label in 2002, and under his direction it has documented his own music, talented stars such as Miguel Zenón, and un-heralded older masters including one of Branford’s teachers, the late Alvin Batiste.  Branford has also shared his knowledge as an educator. He enjoys working with students and has formed an extended relationship with North Carolina Central University where he has been teaching for the past eighteen years. He has also taught at Michigan State University and San Francisco State University and continues to conduct workshops throughout the world.

As for other public stages, Branford spent a period touring with Sting, collaborated with the Grateful Dead and Bruce Hornsby, served as Musical Director of The Tonight Show Starring Jay Leno and hosted National Public Radio’s widely syndicated Jazz Set.  The range and quality of these diverse activities established Branford as a familiar presence beyond the worlds of jazz and classical music, while his efforts to help heal and rebuild New Orleans in the wake of Hurricane Katrina mark him as an artist with an uncommonly effective social vision.  

Together with Harry Connick, Jr. and New Orleans Habitat for Humanity, Branford conceived and helped to realize The Musicians’ Village, a community in the Upper Ninth Ward that provides homes to the displaced families of musicians and other local residents.  The centerpiece of the Village is the Ellis Marsalis Center for Music, honoring Branford’s father. The Center uses music as the focal point of a holistic strategy to build a healthy community and to deliver a broad range of services to underserved children, youth and musicians from neighborhoods battling poverty and social injustice. In January 2024, following in his father’s footsteps, Branford was appointed Artistic Director at the Center and in this capacity, he will shape the artistic trajectory and steer the organization's creative vision for the future.